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Spiroadamantane inhibitor 9 design and its dose response curve on WT, V27A, L26F and S31N inhibition. (a) Structure-based design of spiroadamantane 9. (b) X-ray crystal structure of spiroadamantane 9. (c) Dose response curve of 9 against WT, V27A and S31N A/M2 inhibition.
