Table 1.
Oncolytic Adenoviruses. Some viruses gain tumor-replication selectivity based upon novel gene deletions within their viral genome; others gain selectivity based upon cancer-associated, specific promoter induction.
| Adenoviruses | Tumor-specificity | Clinical Trial | Ref |
|---|---|---|---|
| Wild type | None | N/A | [14, 236] |
| dl1520 (ONYX-015) | E1B-55 kDa-deletion/p53 inhibition | Phases I–III | [84] |
| dl337 | None | N/A | [237] |
| dl118 | E1B-deletion/p53 inhibition | N/A | [238] |
| hTERT-Ad | hTERT promoter specific induction | N/A | [239] |
| ONYX-411 | E2F-1 promoter | N/A | [240] |
| AD.DF3-E1 | DF3 promoter | N/A | [167] |
| CV787 | Rat probasin & PSA promoters | Phase I | [241] |
| CV764 | Human glandular kallikrein & PSA promoters | N/A | [242] |
| CN706 | PSA promoter | Phase I | [19] |