Table 1.

Characteristics of all patients and germline cases^*

	Characteristic	All patients (N=11)	Germline cases (N=5)
Age at diagnosis	Median (Range)	56 (44–75)	56 (44–73)
Smoking history	Never-smoker Former/current smoker	6 (55%) 5 (45%)	4 (80%) 1 (20%)
First-degree relative with lung cancer	Present Absent	3 (27%) 8 (73%)	2 (40%) 3 (60%)
Stage	I II III IV†	2 (18%) 1 (9%) 0 (0%) 8 (73%)	1 (10%) 0 (0%) 0 (0%) 4 (80%)
Histology	Adenocarcinoma	11 (100%)	5 (100%)
EGFR sensitizing mutation	Exon 19 deletion Exon 21 L858R Different mutations in different lesions† No sensitizing mutation	4 (36%) 6 (55%) 1 (9%) 0 (0%)	2 (40%) 2 (40%) 1 (10%) 0 (0%)

^*Two of these patients have been previously reported as part of a separate study6

^†One patient had multiple pulmonary nodules harboring different EGFR sensitizing mutations in addition to T790M, possibly representing multiple primary lung cancers rather than stage IV disease