Table 2.

Summary data for the 12p13.33 SNP rs6489769 associated with squamous cell lung carcinoma risk

Study	Case				Control				ORc	95% CId	Pe
	MAFa	AAb	AGb	GGb	MAFa	AAb	AGb	GGb
NCI	0.35	596	663	165	0.38	1,654	2,025	653	1.23	1.11–1.35	3.18×10−−5
UK1	0.34	261	263	68	0.37	1,053	1,293	352	1.16	1.01–1.32	0.043
UK2	0.33	467	456	115	0.37	381	420	132	1.17	1.03–1.34	0.017
Texas	0.33	131	144	30	0.38	453	500	184	1.22	1.01–1.47	0.036
Combined									1.20	1.12–1.28	2.30×10−8

Results from the NCI squamous cell carcinoma discovery phase, replication series (UK1, UK2 and Texas) and meta-analysis data are reported.

^aMinor allele frequency.

^bCommon homozygous, heterozygous and rare homozygous genotypes.

^cOdds ratio for the A allele.

^d95% confidence interval.

^eTwo-sided P-value.

OR and P-values were based on a fixed effect model. Cochran’s Q test P_het=0.89 and I²=0.