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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Ann Neurol. 2012 Mar;71(3):370–384. doi: 10.1002/ana.22687

Table 2.

Five loci associated with PD at genome-wide significance in the Discovery Set

Locus Chr SNP bp A1/A2 A1 freq Imp/geno1 Odds Ratio p-value Direction of Effect in 5 studies2
SNCA 4q rs356165 90856624 G/A 0.4099 IIIII 1.37 9 × 10−21 +++++−−−−−
MAPT 17q rs242559 42198305 C/A 0.2165 IIIIG 0.78 1 × 10−10 −−−−−
GAK 4p rs11248051 848332 T/C 0.1071 GIIIG 1.35 8 × 10−9 +++++
DGKQ 4p rs11248060 954359 T/C 0.1237 GGGGG 1.35 2 × 10−9 +++++
HLA region 6p rs3129882 32517508 A/G 0.4275 GGGGG 0.83 1 × 10−8 −+ −−−
1

Values for imputed (I) or genotyped (G) status; bold indicates genome-wide significance (p<5 × 10−8)

2

Direction of effects are listed in the following order: PROGENI/GenePD, NIA Phase I, NIA Phase II, HIHG, NGRC