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. Author manuscript; available in PMC: 2013 May 15.
Published in final edited form as: Cancer Res. 2012 May 15;72(10):2578–2588. doi: 10.1158/0008-5472.CAN-11-3732

Figure 4. Restoration of laminin anchorage in breast cancer cells slows cell proliferation.

Figure 4

A) CAMAI cells expressing LARGE (+LARGE) or vector control (−LARGE) were maintained in culture and percent change in OD measurements obtained from MTT assays were plotted against time. Statistically significant differences are shown by * (p ≥ 0.0003) B) CAMAI cells were treated with BrdUrd, fixed and stained with an anti-BrdUrd antibody and propidium iodide and subjected to cell cycle analysis by FACS. The numbers on the pie chart indicated percentage (± standard errors) of cells in each phase of cell cycle. The insert on the right denotes cell cycle phases corresponding to the pie chart as well as the p values representing statistically significant differences between −LARGE and +LARGE. C) Percent change in S phase with (+) or without (−) treatment with laminin fragments E1 and E4 was calculated and plotted as histogram bars for CAMAI cells −LARGE (white bars) and +LARGE (gray bars). Standard errors and p values are shown.