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. Author manuscript; available in PMC: 2013 May 15.
Published in final edited form as: Cancer Res. 2012 May 15;72(10):2578–2588. doi: 10.1158/0008-5472.CAN-11-3732

Figure 7. Reduced LARGE expression is associated with aggressive gliomas and poor patient survival.

Figure 7

A) Normalized mean gene expression levels for LARGE in 36 human glioblastoma samples are displayed. The samples belong to three distinct molecular subclasses; proliferative (samples 1–12), mesenchymal (samples 13–25) and proneural (samples 26–37) which correlate strongly with patient survival. P values shown are relative to Proneural. B) Kaplan Meier survival plots for astrocytomas from the Rembrandt database are displayed with respect to LARGE expression levels. Survival data for all samples (All), samples with down regulated LARGE (− LARGE) and samples excluding LARGE down regulation (+LARGE) are shown. Log-rank test for − LARGE and + LARGE is p ≤ 0.037. Statistically significant association with LARGE expression and poor survival were also obtained in Kaplan Meier survival plots of all gliomas (not shown), p=7.9e-7.