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. 2012 May 14;7(5):e37134. doi: 10.1371/journal.pone.0037134

Table 1. Comparison of BRITER with previously reported osteogenic BMP reporter cell Lines.

S No. Cell Line BMP (ng/ml) Fold Induction (Normalized FF Luc) Fold Induction (Relative Luc) Time (Hrs.) Internal Control Normalized by Ref.
1 C2C12 Cells stably transfected with BRE-FFLuc construct 50 5 N/A 16 None Untreated FFLuc value 12
10 2 N/A 16 None
2 C2C12 Cells stably transfected with BRE-FFLuc construct 19.5 1 N/A 15 None Untreated FFLuc value 14
3 C2C12 Cells stably transfected with BRE-FFLuc construct 100 35 N/A 24 None Untreated FFLuc value 13
0.5 2 N/A 24 None
4 BRITER( BMP depletable osteoblast, stably transfetcted with dual Luciferase construct) 100 35-50 45-100 3 SV-40 RR-Luc SV40-RRLuc as well as untreated FFLuc values In this study
10 N/A 17 3 SV-40 RR-Luc