Table 3.

Main findings (primary outcomes).

	All-cause mortality	Myocardial infarction	Stroke
Diuretics vs.BB	0.90 (0.80 to 1.01)	0.82 (0.68 to 0.98)	0.83 (0.68 to 1.07)
	⊕ ⊕ ⊕ O	⊕ ⊕ OO	⊕ ⊕ OO
Diuretics vs. ACE	1.00 (0.93 to 1.08)	1.00 (0.88 to 1.15)	0.94 (0.81 to 1.10)
	⊕ ⊕ ⊕ O	⊕ ⊕ ⊕ O	⊕ ⊕ ⊕ O
Diuretics vs. CCB	1.03 (0.96 to 1.10)	0.96 (0.84 to 1.07)	1.12 (0.97 to 1.29)
	⊕ ⊕ ⊕ O	⊕ ⊕ ⊕ O	⊕ ⊕ OO
Diuretics vs.alpha-blockers	0.98 (0.87 to 1.12)	0.99 (0.80 to 1.23)	0.85 (0.66 to 1.12)
	⊕ ⊕ ⊕ O	⊕ ⊕ ⊕ O	⊕ ⊕ OO
Diuretics vs.ARB	1.02 (0.92 to 1.14)	0.83 (0.69 to 1.03)	1.02 (0.82 to 1.28)
	⊕ ⊕ OO	⊕ OOO	⊕ OOO
BB vs. ACE	1.12 (0.98 to 1.27)	1.22 (1.00 to 1.52)	1.13 (0.86 to 1.42)
	⊕ OOO	⊕ ⊕ OO	⊕ OOO
BB vs. CCB	1.14 (1.01 to 1.28)	1.17 (0.97 to 1.42)	1.34 (1.05 to 1.64)
	⊕ ⊕ OO	⊕ OOO	⊕ ⊕ OO
BB vs. alpha-blockers	1.09 (0.93 to 1.30)	1.20 (0.92 to 1.61)	1.02 (0.71 to 1.42)
	⊕ OOO	⊕ OOO	⊕ OOO
BB vs. ARB	1.14 (1.02 to 1.28)	1.02 (0.84 to 1.27)	1.23 (0.96 to 1.49)
	⊕ ⊕ ⊕ ⊕	⊕ ⊕ ⊕ O	⊕ ⊕ ⊕ O
ACE vs. CCB	1.02 (0.95 to 1.10)	0.96 (0.83 to 1.07)	1.19 (1.03 to 1.38)
	⊕ ⊕ ⊕ O	⊕ ⊕ ⊕ O	⊕ ⊕ ⊕ O
ACE vs. alpha-blockers	0.98 (0.85 to 1.14)	0.99 (0.77 to 1.27)	0.91 (0.67 to 1.24)
	⊕ ⊕ OO	⊕ OOO	⊕ OOO
ACE vs. ARB	1.02 (0.91 to 1.14)	0.84 (0.68 to 1.04)	1.08 (0.86 to 1.37)
	⊕ ⊕ OO	⊕ OOO	⊕ OOO
CCB vs. alpha-blockers	0.96 (0.83 to 1.11)	1.03 (0.82 to 1.34)	0.77 (0.57 to 1.04)
	⊕ ⊕ OO	⊕ OOO	⊕ OOO
CCB vs. ARB	1.00 (0.91 to 1.10)	0.87 (0.74 to 1.06)	0.91 (0.75 to 1.11)
	⊕ ⊕ ⊕ ⊕	⊕ ⊕ ⊕ O	⊕ ⊕ ⊕ O
Alpha-blockers vs. ARB	1.04 (0.88 to 1.23)	0.84 (0.63 to 1.14)	1.20 (0.85 to 1.69)
	⊕ ⊕ OO	⊕ OOO	⊕ OOO

ACE, Angiotensin Converting Enzyme Inhibitors; ARB, Angiotensin Receptor Blockers; BB, Beta-blockers; CCB, Calcium Channel Blockers; ⊕ ⊕ ⊕ ⊕, High quality evidence; ⊕ ⊕ ⊕ O, Moderate quality evidence; ⊕ ⊕ OO, Low quality evidence; ⊕ OOO, Very low quality evidence