Table 1.
Logistic regression top scoring SNPs, approach I
| Gene Symbol dbSNP RS ID | Distance to Gene | Unadj. p-value | FDR_BH p-value | OR (95% CI) | Pathway/Disease/function |
|---|---|---|---|---|---|
| NISCH rs6784615 | intron | 7.16E-07 | 4.47E-02 | 2.21 (1.61-3.02) | Interaction with PAK4 for reduction of LIMK1 phosphorylation; neuronal migration and axon/dendrite outgrowth [22,23]. |
| RABEP1 rs4356530 | upstream 27742 | 8.59E-07 | 4.47E-02 | 2.21 (1.61-3.02) | Endocytosis [24,32]. |
| THEMIS rs9398855 | intron | 2.25E-06 | 8.78E-02 | 2.13 (1.56-2.92) | Immnune response [25-27]. |
|
NDUFA12 rs249153 |
downstream 40719 | 4.13E-06 | 1.29E-01 | 1.62 (1.32-2.00) | AD, Parkinson's, Hungtinton's, oxidative phosphorylation [28-32]. |
| MUC21 rs2517509 | downstream 72544 | 4.93E-06 | 1.39E-01 | 3.14 (1.92-5.12) | Prevention of cell-cell interaction of Integrins [55]. |
| TUSC1 rs10115381 | upstream 328744 | 5.33E-06 | 1.39E-01 | 2.08 (1.52-2.85) | Shwachman-Diamond syndrome [56]. |
| CTNNA3 rs10996618 | downstream 187123 | 1.19E-05 | 2.03E-01 | 2.03 (1.48-2.78) | AD (4 studies), Adherens junction, Inmune response [10,32]. |
FDR_BH = Benjamini & Hochberg (1995) step-up False Discovery Rate control.