Figure 8. Number of voxels in rats pre-exposed to saline (Sal) and VPA during gestation.

The study design is as explained in Figures 4 and 5. Sal and VPA rats were subdivided into animals that were given an ICV injection of Sal or a vasopressin V_1a receptor antagonist. The groups are: Sal-CSF (open bar), VPA-CSF (close bar), Sal-V_1a (diagonal patterned), and VPA-V_1a (upward patterned). Data correspond to voxel counts per ROI that showed significant BOLD signal increases. Similar to Figure 6, VPA-CSF rats show greater BOLD activation (number of voxels) than Sal-CSF. The V_1a antagonist reduces this effect in VPA rats. Data shown as mean ± standard error. Asterisks and lines indicate specific posthoc comparisons with * p<0.05 and **p<0.01 (two way ANOVA).