Figure 6. Induction of apoptosis in L3.6pl cells.

The cells were treated for 48 h with A) varying concentrations of tubulysin A or pretubulysin (n = 2) or B) with 10 nM drug in conjunction with 10 µM caspase inhibitor Q-VD-OPh (n = 3). The percentages of apoptotic cells in the whole cell population were determined by PI staining (*p≤0.05 Anova/Dunnett).