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. 2012 May 17;7(5):e37365. doi: 10.1371/journal.pone.0037365

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Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Yolk sacs collected at E11.5 were stained for SMA (red) and Pecam1 (green). SMA is prominently expressed around the blood vessels in yolk sacs of wildtype and Notch3^−/− (N2^+/+;N3^−/−) embryos, whereas its expression is significantly decreased in Notch2^−/− (N2^−/−;N3^+/+) and Notch2^−/−;Notch3^−/− (N2^−/−;N3^−/−) vessels. Yolk sacs of the Notch2^−/−;Notch3^−/− embryos have blood vessels that appear structurally deficient compared to the other genotypes. Scale bar = 100 µm.