Figure 4. Viral dynamics in acutely-infected macaques receiving HAART and SIV nucleic acids detection in MGT organs.

4 macaques received a AZT/3TC/IDV combination (HAART 4 h-2 weeks) while 4 others were untreated. (A) Plasma viral load and (B) total viral DNA in PBMCs were measured during the 2 week protocol. Median is represented by a line. The grey area indicates the quantitative threshold of the qRT-PCR and qPCR assays. (C) Frequency of detection of SIV DNA in the seminal vesicle, prostate, epididymis and testis of untreated and 2 week treated macaques, using nested SIV gag PCR. Two independent fragments of each tissue were assayed. Median of frequency is represented by a line.