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. 2012 May 17;7(5):e37092. doi: 10.1371/journal.pone.0037092

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Zhang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Left, schematics of the modified HML locus in strains 17, 19, 22 and 23. Right, growth phenotypes. (B) Left, schematics of the modified HML locus in strains 17n, 19n, 22n and 23n. Right, growth phenotypes. (C) The topoisomers of HML′ circles excised in strains 17, 19, 22, 23 and 17s were fractionated in the presence of 26 µg/ml chloroquine. The profiles of topoisomers were presented on the right.