Table 2. Clinical parameters of control and type 2 diabetic patients.
| Control n = 10 | Normo-albuminuria n = 26 | Micro-albuminuria n = 11 | Macro-albuminuria n = 29 | P value | |
| Men (%) | 40% | 44% | 45% | 53% | 0.85 |
| Age | 61±12.2 | 62±14 | 68±7.3 | 59±13 | <0.0001 |
| HbA1C | – | 7.6 (6.5,8.1) | 7.2 (6.3,8.0) | 7.5 (6.8,9.0) | 0.6 |
| UACR* (mg/g) | 7.32 (3.7,14.5) | 7.9 (5.6,12.8) | 93.8 (79.1,185.4) | 1644.3 (750.3,3013.3) | <0.0001 |
| Serum creatinine (mg/dL) | 0.9 (0.8,1.0) | 1.4 (0.9,1.6) | 1.8 (1.5,2.1) | 2.1 (1.6,2.9) | <0.0001 |
| estimated GFR (ml/min/1.73m2) | 89 (65,120) | 47 (36.2,72.2) | 37 (29,48) | 30 (20,44.5) | <0.0001 |
| Systolic blood pressure (mmHg) | 125 (102,149) | 132 (120,145) | 139 (129,159) | 144 (136,154) | 0.0001 |
| Diastolic blood pressure (mmHg) | 67 (54,85) | 68 (54,76) | 70 (64,72) | 76 (66,88) | 0.21 |
| % Diabetic Retinopathy | – | 43% | 20% | 55% | 0.15 |
| UNCR† (mg/g) | 0.07 (.03,.098) | 0.11(.08,.17)§ | 1.16 (.35,1.60) | 9.15 (5.68,12.08) | <0.0001‡ |
| % ACEI/ARB treatment | 0% (0/10) | 73% (19/26) | 54% (6/11) | 62% (18/29) | 0.0004‡ |
| % UNCR >0.1 (mg/g) | 0% (0/10) | 54% (14/26) | 100% (11/11) | 100% (29/29) | 0.001‡ |
Data are means +/− SD or median (interquartile range).
*
UACR: urine albumin-to-creatinine ratio.
†
UNCR: urine nephrin-to-creatinine ratio.
‡
P for trend across the 4 categories.
§
P <0.05 vs. Control.