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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Hepatology. 2012 Jun 5;56(1):311–321. doi: 10.1002/hep.25624

Fig. 1. Fibrin(ogen) alone forms the initial matrix without fibronectin in response to CCl4-induced acute liver injury.

Fig. 1

(A) Western blot analysis of fibronectin and fibrinogen in control and fibronectin-null livers at 0, 6, 12, 36 and 72hrs after injury under reducing conditions. Pooled samples from 3 mouse livers from each strain were used for the analysis. Band intensity was measured by densitometry and normalized to HSC70 (loading control), then the intensity of the control liver at 0hr was set to 1. Each intensity is shown relative to the control value.

(B) Time-course of fibronectin and fibrin(ogen) deposition in control and Fn-null livers at 12, 36, and 72hrs after injury. Double immunofluorescence staining for fibronectin (in red) and fibrin(ogen) (in green), and the merged images. CV, central vein. Bar=50μm.