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. 2012 Jan 25;20(6):675–681. doi: 10.1038/ejhg.2011.253

Figure 1.

Figure 1

Relationship of P2X7 SNPs with changes in BMD. (a) Post-menopausal change in BMD in non-HRT individuals for the total loss-of-function SNP Arg307Gln. Individuals carrying the mutant allele have an increased rate of bone loss. This is significant for the total hip (TH) 10 years after menopause, and the same trend is present at the LS and FN (top panel). Furthermore, a similar trend is seen after the first 5 years after menopause (bottom panel). The number of individuals with the two genotypes was 860 GG and 16 GA after 5 years and 758 GG and 15 GA after 10 years. No study participants were homozygous for the variant A allele. (b) The presence of Arg307Gln variant, increases the rate of bone loss at the femoral neck (0–5 years) despite HRT treatment. (c) Changes in BMD associated with the Ile568Asn variant over 5 years post menopause. Individuals homozygous for the variant allele (AA) have significantly accelerated bone loss in the femoral neck, with the same trend seen at TH and LS. *P-value <0.05; LS, lumbar spine; FN, femoral neck; NS, not significant; TH, total hip.