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. 2012 Mar 2;127(2):496–507. doi: 10.1093/toxsci/kfs098

TABLE 2.

Serum Biochemistry

BFR mixture nominal doses (mg/kg/day)
Parameter Control (0) 0.02 0.2 2 20 p
Calcium (mg/dl) 13.7 ± 0.2 (10) 13.6 ± 0.2 (8) 13.2 ± 0.3 (9) 13.6 ± 0.2 (10) 13.4 ± 0.2 (10) 0.51
Magnesium (mg/dl) 3.40 ± 0.10 (8) 3.65 ± 0.10 (7) 3.49 ± 0.09 (7) 3.52 ± 0.11 (9) 3.42 ± 0.10 (8) 0.51
Phosphorus (mg/dl) 9.11 ± 0.34 (8) 9.71 ± 0.30 (6) 9.65 ± 0.54 (7) 10.2 ± 0.42 (9) 9.38 ± 0.26 (10) 0.30
Blood urea N 17.1 ± 0.82 (9) 17.2 ± 0.53 (9) 17.1 ± 0.78 (9) 17.5 ± 0.55 (10) 17.5 ± 0.49 (10) 0.99
Uric acid (mg/dl) 3.18 ± 0.34 (10) 2.62 ± 0.25 (9) 2.89 ± 0.27 (9) 2.47 ± 0.31 (10) 2.09 ± 0.25 (10) 0.096
Albumin (g/dl) 3.40 ± 0.05 (8) 3.41 ± 0.10 (4) 3.42 ± 0.04 (7) 3.38 ± 0.05 (8) 3.44 ± 0.05 (6) 0.96
Total protein (g/dl) 7.77 ± 0.10 (10) 7.97 ± 0.12 (8) 7.81 ± 0.13 (9) 7.91 ± 0.14 (10) 7.95 ± 0.11 (10) 0.71
Creatinine kinase (U/l) 227 ± 22 (9) 179 ± 14 (9) 215 ± 29 (9) 275 ± 41 (10) 383 ± 87 (10) 0.20
Creatinine (mg/dl) 0.53 ± 0.02 (9) 0.49 ± 0.02 (9) 0.50 ± 0.01 (9) 0.49 ± 0.01 (10) 0.49 ± 0.01 (10) 0.37
Triglycerides (mg/dl) 184 ± 29 (8) 226 ± 29 (8) 177 ± 19 (7) 248 ± 49 (10) 173 ± 35 (8) 0.48
Cholesterol (mg/dl) 109 ± 5 (10) 117 ± 7 (9) 118 ± 8 (9) 118 ± 7 (10) 127 ± 8 (10) 0.48
Glucose (mg/dl) 296 ± 16 (9) 283 ± 9 (9) 289 ± 16 (8) 255 ± 15 (10) 238 ± 15* (9) 0.03
ALP (U/l) 184 ± 16 (8) 199 ± 21 (6) 202 ± 17 (8) 191 ± 18 (10) 187 ± 9 (8) 0.95
ALT (U/l) 67.9 ± 3.6 (10) 64.9 ± 3.6 (9) 75.4 ± 6.3 (8) 65.4 ± 2.1 (10) 69.5 ± 3.8 (10) 0.40

Notes. Values are expressed as mean ± SEM of (n) observations per treatment. Values in bold are significantly different from control.

*p < 0.05 compared with control.