TABLE 1.
Necrosis |
Neutrophils |
|||
Time (h) | WT | Gal-3−/− | WT | Gal-3−/− |
CTL | 0 | 0 | 0 | 0 |
6 | 2.0 ± 0.0 | 2.0 ± 0.0 | 0 | 0 |
24 | 3.0 ± 0.0 | 2.7 ± 0.3 | 1.0 ± 0.0 | 1.3 ± 0.3 |
48 | 3.0 ± 0.0 | 2.0 ± 0.6 | 2.0 ± 0.0 | 2.0 ± 0.6 |
72 | 2.3 ± 0.3 | 0.3 ± 0.3 | 3.3 ± 0.3 | 0.7 ± 0.3 |
Notes. WT and Gal-3−/− mice were treated with 300 mg/kg APAP or PBS control (CTL). Liver sections were prepared 6–72 h later for histopathological analysis. Findings were graded on a scale of 0–4, where 0 = none, 1 = minimal, 2 = mild, 3 = moderate, 4 = severe changes. Data are expressed as mean ± SE (n = 3 mice).