TABLE 1.

Histopathological Evaluation of Hepatic Necrosis and Neutrophilic Infiltrates in WT and Gal-3^−/− Mice After APAP Administration

	Necrosis		Neutrophils
Time (h)	WT	Gal-3−/−	WT	Gal-3−/−
CTL	0	0	0	0
6	2.0 ± 0.0	2.0 ± 0.0	0	0
24	3.0 ± 0.0	2.7 ± 0.3	1.0 ± 0.0	1.3 ± 0.3
48	3.0 ± 0.0	2.0 ± 0.6	2.0 ± 0.0	2.0 ± 0.6
72	2.3 ± 0.3	0.3 ± 0.3	3.3 ± 0.3	0.7 ± 0.3

Notes. WT and Gal-3^−/− mice were treated with 300 mg/kg APAP or PBS control (CTL). Liver sections were prepared 6–72 h later for histopathological analysis. Findings were graded on a scale of 0–4, where 0 = none, 1 = minimal, 2 = mild, 3 = moderate, 4 = severe changes. Data are expressed as mean ± SE (n = 3 mice).