TABLE 2.

Effects of APAP on Serum Transaminases in WT and Gal-3^−/− Mice

	ALT (U/l)		AST (U/l)
Time (h)	WT	Gal-3−/−	WT	Gal-3−/−
CTL	32.1 ± 2.6	45.4 ± 7.2	60.6 ± 5.6	82.5 ± 10.6
6	7797.0 ± 508.1a	6363.1 ± 1266.9	7473.0 ± 481.8a	7711.1 ±1917.4a
24	10,905.8 ± 825.5a	7673.6 ± 1022.9a,b	6391.1 ± 911.4a	3908.2 ± 723.6a
48	1194.0 ± 126.1a	454.2 ± 53.5b	522.9 ± 51.8a	265.7 ± 26.5b
72	247.6 ± 41.4	116.6 ± 15.1b	261.4 ± 29.3	93.8 ± 15.4b

Notes. ALT, alanine aminotransferase; AST, aspartate aminotransferase. WT and Gal-3^−/− mice were treated with 300 mg/kg APAP or PBS control (CTL). Sera were collected 6–72 h later and analyzed for ALT and AST. Data are expressed as mean ± SE (n = 5–12 mice).

^aSignificantly different (p < 0.05) from CTL.

^bSignificantly different from WT.