Table 2.

Selectivity and Binding of QN254 on PfDHFR and hDHFR

Compound	Ki (nM)			Ki Ratio
	WT-PfDHFRa	QM-PfDHFRb	hDHFRc	h/Pf-DHFR
Cycloguanil	1.51 ± 0.1	454 ± 38	55.6 ± 7.8	37
Pyrimethamine	0.59 ± 0.05	385 ± 163	30.8 ±1.4	52
QN254	0.39 ± 0.05	0.58 ± 0.06	10.2 ± 0.6	26

^awild type PfDHFR

^bquadruple mutant PfDHFR,

^chuman DHFR.