Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The Activity of Piperidyl Benzamides on Drug Resistant Strains
| Compound | R1 | R2 |
P. falciparum 3D7 EC50 (µM)a |
P. falciparum W2 EC50 (µM)a |
|---|---|---|---|---|
| 11 | Cl |  |
0.134 ± 0.056 | 0.888 ± 0.112 |
| 12 | Cl |  |
0.097 ± 0.018 | 0.276 ± 0.014 |
| 13 | CF3 |  |
0.149 | 0.299 |
| 14 | Cl |  |
0.140 | 0.323 |
| 15 | CF3 |  |
0.058 | 0.211 |
Values are mean of two experiments. Each assay plate has mefloquine, sulfadoxine and artemisinin as internal standards. The EC50 values for standard compounds match literature values.
