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. Author manuscript; available in PMC: 2012 Sep 15.
Published in final edited form as: Cancer Res. 2011 Jul 25;71(18):6061–6072. doi: 10.1158/0008-5472.CAN-10-4269

Figure 1. NOTCH receptor-expressing cells are co-localized with NESTIN-positive tumor cells in primary GBM and have elevated level of NOTCH activity adjacent to NOTCH-ligand expressing cells.

Figure 1

(A) Expression of NOTCH1 and NESTIN was co-localized in the same cells in the primary GBM tumors (GBM-071409, GBM-032410, and GBM-022610). (B) JAG1-expressing cells or DLL1-expressing cells (green, arrowhead) were adjacent to HES5-expressing cells (red, arrow) in primary GBM samples. (C) NOTCH1- or NOTCH2-expressing cells were co-localized with HES5-expressing cells (arrow) in primary GBM samples.