. Author manuscript; available in PMC: 2013 Apr 12.

Published in final edited form as: J Med Chem. 2012 Mar 22;55(7):3387–3397. doi: 10.1021/jm300072d

Table 2.

Kinetic parameters of compound 1

Protease	K_m (μM)	k_cat (min⁻¹)	k_cat/K_m (min⁻¹·μM⁻¹)	K_i (nM)
PR_WT	30 ± 5^a	194 ± 23^a	7.4 ± 1.2^a	0.44 ± 0.05
PR_I47V	24 ± 3	225 ± 11	9.0 ± 1.5	0.46 ± 0.04
PR_L76V	37 ± 6^b	334 ± 23^b	9.0 ± 1.5^b	0.80 ± 0.08
PR_V82A	29 ± 3	512 ± 26	17.7 ± 2.0	0.65 ± 0.05
PR_N88D	65 ± 13	265 ± 29	4.1 ± 1.2	0.92 ± 0.10

Data previously reported in Liu et al.⁴⁹

Data previously reported in Louis et al.²⁰