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Schematic presentation of spliceosomal assembly and catalytic cycle. The scheme is drawn according to Wahl et al. (2009) indicating the assembly phase specific regulatory roles of key ATP-dependent DExH/D-box RNA helicases (in red) and the spliceosome-activating NTC complex. 5′ and 3′ splice site (5′SS and 3′SS), branch point (BP), and polypyrimidine tract (PPT). Exons are indicated by gray boxes, while thin black lines show intron and intron lariat.
