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. 2012 Jan 31;7(5):811–816. doi: 10.1021/cb2004516

Figure 2.

Figure 2

Structures of CDK2/cyclin A/CAN508 and CDK9/cyclin T/CAN508. (a) CDK2 (orange) and CDK9 (green) are shown as ribbon representations, with CAN508 molecules as stick models. The glycine-rich loop is indicated. (b) Chemical structure of CAN508. (c, d) The CDK9/cyclin T (c) and CDK2/cyclin A (d) ATP binding sites complexed with CAN508. Contacting residues within 3.5 Å are drawn as stick models, and hydrogen bonds are indicated by dotted lines. (e) Superposition of selected ATP binding site residues in active CDK2 (orange) and CDK9 (green). CDK9 residues are labeled. Figures were prepared using PyMOL.