Figure 2.

Proposed structure of wild type and mutated SFD1 proteins based on the structure of a Leishmania mexicana G3P dehydrogenase. A ribbon model of the Leishmania mexicana 1EVYA GPDH enzyme based on its crystal structure is shown. The structure of the wild type SFD1 protein (SFD1-WT) and the SFD1–Ala194, SFD1–Ala279, and SFD1–Ala332 proteins in which residues Lys194, Lys279, and Asp332 are replaced by Ala (denoted as beads), were modeled based on the structure of 1EVYA with the SWISS-MODEL and RasMol 2.7.4.2 www.rasmol.org softwares.