Figure 2.

Phosphoinositide pathway functions reported in animal and yeast nuclei. In animals and yeast, phospholipids and inositol phosphates are associated with many critical nuclear processes such as DNA repair, chromatin remodeling and RNA editing and export as described in the text. Nuclear enzymes affected by the PI pathway include: polyadenylate polymerase (PAP), topoisomerase, DNA polymerase and RNA polymerase. Nuclear proteins include: transcription factors (TF), inositol phosphate kinase 2 (IPK2, with transcription factor activity), inositol trisphosphate receptor (InsP₃R), histone H1 (H1), histones 2A, 2B, 3 and 4 (Histone Octomer). Nuclear complexes include: DNA repair complex with Non-homologous end joining (NHEJ), RNA editing, mRNA export, Spliceosome, Remodeling complexes, Telomerase complex and the NPC – nuclear pore complex. Data are from both in vivo and in vitro assays. Small circles represent different phospholipids and small squares represent different inositol phosphates as indicated.