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Results of epistasis analysis for regulatory motifs in Figures 4A,B, respectively.
| Gene state/mutation | X | Y | Z |
|---|---|---|---|
| A | |||
| x | 0 | 1 | 0 |
| y | 1 | 0 | 1 |
| xy | 0 | 0 | 1 |
| WT | 1 | 0 | 1 |
| B | |||
| x | 0 | 1 | 0 |
| y | 0 | 0 | 1 |
| Xy | 0 | 0 | 1 |
| WT | 1 | 1 | 1 |
Given that these are switch regulatory pathways, the presence of a substrate, as explained by Huang and Sternberg (2006), is neglected and epistasis analysis may discern between them only with additional experiments.
