Table 2.
Polymorphism in the xenometabolic gene and risk of kidney cancer (codominant model).
| SNP amino acid change or gene region | rs Number | HWE | % homozygous wild type |
OR (95% confidence interval) for risk with variant | SNP | rs Number | HWE | % homozygous wild type |
OR (95% confidence interval) for risk with variant | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cases | controls | cases | controls | |||||||||
| NAT1 A40T | rs4986989 | 0.34 | 91.4 | 93.4 | 1.33 (0.97, 1.83) | NAT2Ex2 + 1750T > G | rs4646249 | 0.37 | 52.9 | 54.2 | 1.05 (0.90, 1.23) | |
| NAT1 R187Q | rs4986782 | 0.11 | 96.6 | 98.0 | 1.61 (0.97, 2.65) | NAT2IVS1 + 3214G > C | rs7011792 | 0.37 | 37.2 | 35.2 | 0.94 (0.81, 1.09) | |
| NAT1 C344T | rs4986988 | 0.64 | 91.3 | 92.8 | 1.17 (0.88, 1.57) | NAT2 Ex2 + 624A > G | rs721398 | 0.87 | 46.7 | 47.2 | 1.02 (0.88, 1.19) | |
| NAT1 V149I | rs4987076 | 0.29 | 91.4 | 92.8 | 1.17 (0.87, 1.57) | NAT2 − 23931C > T | rs7006687 | 0.85 | 31.6 | 29.3 | 0.95 (0.82, 1.09) | |
| NAT1 T1088A | rs1057126 | 0.68 | 64.5 | 64.7 | 1.01 (0.87, 1.17) | NAT2 5276 bp 3′ of STP A > C | rs12674710 | 0.41 | 68.0 | 73.3 | 1.16 (0.96, 1.40) | |
| NAT1 C1095A | rs15561 | 0.61 | 55.3 | 55.5 | 1.02 (0.89, 1.17) | COMTV158M | rs4680 | 0.36 | 27.7 | 27.6 | 1.00 (0.89, 1.13) | |
| NAT1 Ex2T > C NAT1 | rs10888150 | 0.86 | 34.9 | 34.6 | 1.06 (0.92, 1.22) | CYP1A1 I462V | rs1048943 | 0.96 | 91.7 | 92.6 | 1.03 (0.76, 1.41) | |
| IVS1 + 3238G > A NAT1 | rs203943 | 0.45 | 83.2 | 82.3 | 0.94 (0.73, 1.21) | CYP1A1 T3801C | rs4646903 | 0.32 | 80.8 | 80.0 | 0.95 (0.78, 1.16) | |
| IVS 1 + 4218A > G | rs13253389 | 0.62 | 41.4 | 43.0 | 1.07 (0.92, 1.24) | CYP1A2A164C | rs762551 | 0.86 | 47.5 | 46.2 | 0.97 (0.86, 1.10) | |
| NAT1 IVS1 − 1014T > A | rs4921880 | 0.68 | 59.9 | 57.9 | 0.93 (0.78, 1.10) | CYP1A2G3858A | rs2069514 | 0.62 | 95.9 | 96.5 | 1.10 (0.72, 1.69) | |
| NAT1 IVS1 − 2978A > G | rs6586714 | 0.42 | 71.7 | 73.3 | 1.13 (0.92, 1.38) | CYP1A2N516N | rs2470890 | 0.46 | 39.8 | 37.4 | 0.93 (0.83, 1.06) | |
| NAT1 IVS2 + 312T > C | rs7003890 | 0.34 | 30.5 | 26.6 | 0.95 (0.82, 1.09) | CYP1B1 V432L | rs1056836 | 0.25 | 32.1 | 35.9 | 1.13 (1.01, 1.27) | |
| NAT1 IVS1 + 385A > G | rs7017402 | 0.68 | 79.0 | 79.5 | 1.04 (0.83, 1.30) | CYP1B1 N453S | rs1800440 | 0.27 | 73.1 | 70.1 | 0.91 (0.78, 1.07) | |
| NAT1 IVS1 − 3738T > C | rs9325827 | 0.73 | 72.4 | 72.2 | 0.95 (0.78, 1.17) | CYP2A6 L160H | rs1801272 | 0.65 | 96.0 | 96.6 | 1.07 (0.67, 1.71) | |
| NAT1 Ex3 + 1010G > A | rs9650592 | 0.97 | 80.2 | 78.8 | 0.93 (0.74, 1.17) | CYP2C9 R430C | rs1799853 | 0.58 | 86.2 | 86.3 | 1.05 (0.86, 1.28) | |
| NAT1 − 27893G > A | rs11778588 | 0.57 | 87.1 | 85.6 | 0.92 (0.69, 1.21) | CYP2C9 I359L | rs1057910 | 0.58 | 80.0 | 79.3 | 1.03 (0.82, 1.29) | |
| NAT1 − 23972T > A | rs4921877 | 0.42 | 54.6 | 56.5 | 1.06 (0.91, 1.25) | CYP2E1 G1293C | rs3813867 | 0.79 | 94.8 | 95.0 | 1.07 (0.74, 1.56) | |
| NAT1 8827 bp 3′ of STP C > G | rs7829368 | 0.79 | 47.2 | 45.3 | 0.97 (0.83, 1.13) | CYP2E1 G71T | rs6413420 | 0.22 | 90.3 | 90.4 | 0.98 (0.74, 1.28) | |
| NAT1 − 28011A > G | rs7823976 | 0.57 | 33.8 | 32.0 | 0.95 (0.82, 1.09) | CYP3A4 A392G | rs2740574 | 0.54 | 93.4 | 92.6 | 0.92 (0.66, 1.27) | |
| NAT2I114T | rs1801280 | 0.14 | 33.9 | 31.2 | 0.94 (0.83, 1.06) | MEH H139R | rs2234922 | 0.21 | 64.2 | 61.5 | 0.89 (0.76, 1.03) | |
| NAT2 C481T | rs799929 | 0.09 | 36.0 | 33.7 | 0.92 (0.82, 1.04) | MEHY113H | rs1051740 | 0.90 | 43.6 | 45.2 | 1.01 (0.89, 1.15) | |
| NAT2R197Q | rs1799930 | 0.63 | 47.9 | 48.3 | 1.01 (0.89, 1.15) | NQ01 P187S | rs1800566 | 0.64 | 64.0 | 66.4 | 1.13 (0.98, 1.31) | |
| NAT2 L268R | rs1208 | 0.08 | 35.1 | 31.8 | 0.92 (0.81, 1.04) | NQ01 R139W | rs4986998 | 0.71 | 94.3 | 94.8 | 0.99 (0.69, 1.41) | |
| NAT2 C282T | rs1041983 | 0.55 | 45.4 | 45.4 | 0.98 (0.86, 1.11) | NQ01 − 3617C > G | rs2917666 | 0.26 | 43.3 | 47.1 | 1.15 (0.96, 1.37) | |
| NAT2 G286E | rs1799931 | 0.87 | 95.8 | 95.6 | 0.89 (0.59, 1.33) | NQ01 IVS1 + 1116T > C | rs2917669 | 0.71 | 74.5 | 75.3 | 1.09 (0.94, 1.27) | |
| NAT2IVS1 − 1799A > G | rs1961456 | 0.62 | 52.7 | 53.2 | 1.04 (0.89, 1.22) | NQ01 − 4069G > A | rs1469908 | 0.31 | 33.6 | 38.2 | 1.09 (0.94, 1.26) | |
| NAT2IVS1 − 3041T > C | rs2410556 | 0.14 | 77.8 | 75.6 | 0.82 (0.66, 1.02) | UGT1A7N12 | rs17868323 | 0.30 | 40.7 | 40.0 | 0.99 (0.87, 1.12) | |
| NAT2 Ex2G > C | rs4271002 | 0.64 | 78.5 | 75.8 | 0.85 (0.68, 1.06) | |||||||
*OR (95% CI) by unconditional logistic regression, controlling for age, sex, study center, blood pressure, BMI, pack-years of smoking, and alcohol use. Hardy–Weinberg equilibrium (HWE) as measured in the control population.