Table 1.
Comparison of the static parameters between treatments with tiotropium and oxitropium
| Tiotropium | Oxitropium | P value | |
|---|---|---|---|
| Body mass index (kg/m2) | 22.3 ± 2.3 | 22.2 ± 2.4 | |
| FEV1 (L) | 1.06 ± 0.39 | 0.97 ± 0.43 | 0.003 |
| % FEV1 (% pred) | 42.0 ± 14.7 | 38.6 ± 16.4 | 0.003 |
| FVC (L) | 2.33 ± 0.74 | 2.05 ± 0.77 | 0.002 |
| FVC (% pred) | 75.8 ± 18.4 | 66.9 ± 21.0 | 0.002 |
| FEV1/FVC (%) | 45.7 ± 10.4 | 48.7 ± 12.7 | |
| IC (L) | 1.81 ± 0.43 | 1.74 ± 0.48 | |
| DL, CO % pred | 72.4 ± 25.2 | 70.7 ± 27.6 | |
| RV/TLC (%) | 45.3 ± 6.1 | 48.5 ± 8.8 | |
| Respiratory frequency | 19.3 ± 4.4 | 21.5 ± 4.1 | 0.04 |
| Tidal volume (mL) | 647 ± 124 | 618 ± 165 | |
| Minute ventilation (L/minute) | 11.9 ± 2.5 | 12.4 ± 2.6 | |
| Oxygen uptake (mL/minute) | 218 ± 42.1 | 230 ± 53.6 | |
| pH | 7.41 ± 0.02 | 7.40 ± 0.03 | |
| PaO2 (mmHg) | 86.5 ± 11.9 | 78.6 ± 7.9 | 0.002 |
| PaCO2 (mmHg) | 37.9 ± 4.3 | 39.3 ± 4.2 | 0.024 |
| Lactate (mEq/L) | 1.16 ± 0.44 | 0.96 ± 0.30 | |
| Norepinephrine (ng/mL) | 0.61 ± 0.32 | 0.64 ± 0.29 |
Note: Data are presented as mean ± standard deviation.
Abbreviations: % pred, percent predicted; DL, CO, diffusing capacity for carbon monoxide; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; IC, inspiratory capacity; PaCO2, arterial carbon dioxide pressure; PaO2, arterial oxygen pressure; RV, residual volume; TLC, total lung capacity.