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Domain organization of VHL box proteins. (A) The VHL box consists of a BC box and a Cul2 box in the order indicated. LRR, leucine-rich repeats; SWIMZ, SWI2/SNF2 MuDR zinc fingers. (B) Alignment of amino acid sequences of selected Cul2 boxes. Identical amino acids are highlighted in yellow. GenBank™ accession numbers of each protein are indicated. The consensus sequence is indicated below. Φ, hydrophobic residue.
