Table 1.

Summary of phenotypes from the five different Fto rodent models.

	Rodent models of Fto			Body weight	Body composition	Energy uptake	Energy expenditure
ONLY IN HOMOZYGOUS KNOCKOUTS
Global Fto knockout	Fischer et al. (2009)	Mice	Fto−/−	↓	↓Lean and fat mass	↑	↑
BOTH IN HOMOZYGOUS AND HETEROZYGOUS MUTANTS
Global Fto mutation	Church et al. (2009)	Mice	FtoI367F	↓	↓Fat mass; no change in lean mass	No change	↑
Global Fto overexpression	Church et al. (2010)	Mice	Fto-3 Fto-4	↑	Fat mass; no change in lean mass	↑	No change
ARC-specific Fto manipulation	Tung et al. (2010)	Rats	Ftooverexpress	No change	No data	↓	No data
		Rats	Ftoknockdown	No change	No data	↑	No data
ONLY IN HOMOZYGOUS KNOCKOUTS
Brain-specific Fto knockout	Gao et al. (2010)	Mice	Fto−/−	↓	↓Lean and fat mass	↑	↑