Table 3.
Top 20 most similar regulated genes in the group of five experiments.
Gene | StdDev | Function | bra | brc | hox | ERG | not | C+ | C− |
---|---|---|---|---|---|---|---|---|---|
DDX50 | 0.048 | RNA helicase | −0.15 | −0.27 | −0.15 | −0.18 | −0.14 | 1 | 1 |
USP2 | 0.058 | Peptidase | 0.27 | 0.38 | 0.22 | 0.35 | 0.29 | 1 | 26 |
NCAPD2 | 0.059 | Protein binding | −0.22 | −0.22 | −0.14 | −0.09 | −0.08 | 21 | 3 |
DARC | 0.067 | Cytokine binding | 0.18 | 0.27 | 0.15 | 0.33 | 0.21 | 4 | 46 |
CCR3 | 0.069 | Cytokine binding | 0.4 | 0.49 | 0.38 | 0.33 | 0.51 | 0 | 0 |
NUP37 | 0.07 | Nuclear pore | −0.25 | −0.14 | −0.07 | −0.21 | −0.08 | 17 | 1 |
PSMG1 | 0.071 | Chaperone | −0.2 | −0.07 | −0.19 | −0.22 | −0.04 | 17 | 6 |
IDI1 | 0.072 | Isomerase | −0.16 | −0.18 | −0.19 | −0.21 | −0.01 | 1 | 6 |
LRIT1 | 0.072 | Protein binding | 0.22 | 0.17 | 0.29 | 0.39 | 0.28 | 0 | 1 |
NOL4 | 0.075 | DNA binding | 0.28 | 0.38 | 0.31 | 0.46 | 0.25 | 5 | 10 |
RPA2 | 0.075 | DNA replication | −0.28 | −0.12 | −0.15 | −0.06 | −0.11 | 2 | 1 |
CHST1 | 0.076 | Transferase | 0.31 | 0.29 | 0.12 | 0.21 | 0.14 | 5 | 3 |
PCBP1 | 0.078 | Translation regulator | −0.2 | −0.1 | −0.18 | −0.25 | −0.03 | 2 | 2 |
HAT1 | 0.079 | Transferase | −0.17 | −0.04 | −0.18 | −0.26 | −0.07 | 18 | 1 |
ADNP2 | 0.079 | Transcription regulator | −0.28 | −0.1 | −0.15 | −0.04 | −0.18 | 3 | 1 |
CD7 | 0.079 | Receptor | 0.29 | 0.19 | 0.14 | 0.36 | 0.28 | 2 | 8 |
DEK | 0.08 | Transcription regulator | −0.23 | −0.08 | −0.08 | −0.25 | −0.07 | 17 | 3 |
EED | 0.081 | Transferase | −0.26 | −0.16 | −0.2 | −0.15 | −0.02 | 1 | 2 |
KDR | 0.081 | Growth factor receptor | 0.25 | 0.34 | 0.2 | 0.39 | 0.17 | 1 | 11 |
EDNRA | 0.081 | Peptide receptor | 0.23 | 0.22 | 0.18 | 0.33 | 0.08 | 31 | 17 |
Notes: Values are log10 ratios between induced and control. C+/C−: number significant unique analyses of cancer tissue in the Oncomine database showing up/down-regulation in the 10% rank percentile, P-value below 1e-4 and fold-change above 2.0.
Abbreviations: StdDev, standard deviation; bra, BRAF+; brc, BRCA1−; hox, HOXA9−; ERG, ERG+; not, NOTCH1−.