Table 1.
Involvement of CUL4A substrates in pathogenesis.
| DCAF | Substrate | Substrate functions | Associated pathogenesis | Reference |
|---|---|---|---|---|
| DDB2 | DDB2 | Nucleotide excision repair; DCAF substrate receptor. | Xeroderma pigmentosum; skin cancer | Nichols et al. (2000), Chen et al. (2001), Groisman et al. (2003), Nag et al. (2001), Sugasawa et al. (2005) |
| DDB2 | XPC | Nucleotide excision repair | Xeroderma pigmentosum, skin cancer | Sugasawa et al. (2005) |
| Cdt2 | p21/CIP/WAF1 | CDK inhibitor | Normal cell cycle and DNA damage response | Abbas et al. (2008), Kim et al. (2008), Nishitani et al. (2008) |
| Cdt2 | Cdt1 | DNA replication licensing factor | DNA re-replication | Higa et al. (2006a), Jin et al. (2006) |
| Cdt2 | PR-Set7/Set8 | Histone methyltransferase | Unknown | Abbas et al. (2010), Centore et al. (2010), Jorgensen et al. (2011), Oda et al. (2010), Tardat et al. (2010) |
| Fbw5 | Tsc2 | Inhibitor of mTOR signaling | Tuberous sclerosis | Hu et al. (2008) |
| β-TrCP | REDD1 | Inhibitor of mTOR signaling | unknown | Katiyar et al. (2009) |
| RBBP7 | p150/Sal2 | Inhibitor of cell growth | Putative tumor suppressor | Sung et al. (2011) |
| RASSF1A | Inhibitor of Ras signaling | Putative tumor suppressor | Jiang et al. (2011) | |
| TRCP4AP/TRUSS | N-Myc, C-Myc | Transcription factors | Oncoproteins, multiple tumors | Choi et al. (2010) |
| COP1 | c-Jun | Transcription factor | Oncoprotein, multiple tumors | Wertz et al. (2004) |
| COP1 | p53 | Transcription factor | Tumor suppressor | Dornan et al. (2004) |
| COP1 | ETV1 | Transcription factor | Oncoprotein, prostate cancer | Vitari et al. (2011) |
| DCAF1/VprBP | unknown | Cell cycle regulator | Oncoprotein. Inhibited by the Merlin tumor suppressor | Li et al. (2010) |
| Cereblon | unknown | Limb development/patterning | Terotogenic, multiple myeloma. Inhibited by thalidomide | Ito et al. (2010) |
| Unknown | HOXA9 | Transcription factor | Acute myeloid leukemia | Zhang et al. (2003) |
| Unknown | p27/Kip1 | CDK inhibitor | Tumor suppressor | Higa et al. (2006b) |
| Unknown | cyclin E | Cell cycle progression | Oncoprotein, multiple tumors | Higa et al. (2006b) |
| Unknown | Chk1 | Cell cycle checkpoint kinase | Tumor suppressor | Zhang et al. (2005), Leung-Pineda et al. (2009), Guervilly et al. (2011) |