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Biosynthetic pathway for gonadal steroid hormones. (A) Shows known enzymes and intermediates leading to the synthesis of estrogens and androgens from cholesterol. (B) Shows the metabolic steps of dihydrotestosterone processing putatively involved in pre-receptor regulation of ERbeta activation. 3α-Diol = 5α androstane 3α, 17β Diol; 3β Diol = 5α androstane 3β, 17β Diol, RL-HSD = 11-cis-retinol dehydrogenase like 3α-HSD.
