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Immunophenotypic and genomic features of ALCL.
| ALCL |
||
|---|---|---|
| ALCL ALK+ | ALCL ALK− | |
| IMMUNOPHENOTYPIC FEATURES | ||
| CD30 | +++ | +++ |
| CD2 | + | ++ |
| CD3 | −/+ | + |
| CD4 | +/++ | +/++ |
| CD8 | + | + |
| CD43 | +/++ | +/++ |
| CD56 | −/+ | −/+ |
| TIA1, granzyme B, or perforin | +++ | +++ |
| NFTAC | − | − |
| pSHP2 | +/++ | −/+ |
| p-STAT3 | +++ | + |
| C/EPBβ | +++ | + |
| PDGFRα | −/+ | −/+ |
| EMA | +++ | ++ |
| CD15 | −/+ | −/+ |
| PAX5 | − | − |
| GENETICS | ||
| TCR γ/β | +++ | +++ |
| IgH/L | − | − |
| EBV | − | − |
+++, X > 75%; ++, 50% < X < 75%; +, 25% < X < 50%; −/+, X < 25%. −, X = 0%.
