Table 1.
Low affinity GPCRs for metabolites and metabolic intermediates.
| Receptor name | Previous name | Ligand | Ratified by IUPHAR? | Ligand source |
|---|---|---|---|---|
| FFA1 | GPR40 | Medium and long chain free fatty acids | Yes | Food; fatty acid metabolism; β-oxidation |
| FFA2 | GPR43 | Short chain free fatty acids | Yes | Breakdown of fiber |
| FFA3 | GPR41 | Short chain free fatty acids | Yes | Breakdown of fiber |
| GPR35 | Kynurenic acid (lysophosphatidic acid) | No | Tryptophan metabolism | |
| HCA1 | GPR81 | Lactate | Yes | Glycolysis |
| HCA2 | GPR109A | β-Hydroxybutyrate | Yes | HMG-CoA ketogenesis pathway |
| HCA3 | GPR109B | 3-Hydroxy-octanoic acid | Yes | β-Oxidation |
| GPR120 | Long chain free fatty acids | No | Food; fatty acid metabolism; β-oxidation | |
| GPBA | TGR5 | Bile acids | Yes | Cholesterol metabolism |
| SUCNR1 | GPR91 | Succinate | No | Citric acid cycle |