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. 2011 Dec 2;2:90. doi: 10.3389/fendo.2011.00090

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Copyright © 2011 Micevych and Sinchak.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

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Blocking neuroprogesterone synthesis alters the pattern of estrous cycles in gonadally intact rats. The 4-day rat estrous cycle is diagrammatically presented. Each day of the cycle is indicated on the ordinate: D1, diestrous day 1; D2, diestrous day 2; P, proestrus; and E, estrus. Neuroprogesterone synthesis was blocked by infusion of a P450scc inhibitor, aminoglutethimide (AGT), into the third ventricle (3V) via an implanted cannula. All animals treated with DMSO (5%, vehicle n = 14; data not shown) had normal 4 day estrous cycles as determined by vaginal cytology. In contrast, 11/14 AGT treated rats (0800 hours on proestrus, indicated by the arrow) had disrupted estrous cycles with delayed onset of estrous as determined by vaginal cytology (from Micevych and Sinchak, 2008a).