Table 1.
Effects of a high fat diet on Pgc-1α and Ucp1 mRNA levels.
| Strain and mRNA | LFD mRNA | HFD mRNA | P-value | n |
|---|---|---|---|---|
| AJ Ucp1 | 222 ± 20 | 186 ± 42 | 0.43 | 12 |
| B6 Ucp1 | 9.5 ± 2 | 33 ± 10 | 0.02 | 12 |
| B × AF1 Ucp1 | 38 ± 7 | 55 ± 12 | 0.22 | 12 |
| AJ Pgc-1α | 13 ± 1 | 21 ± 2 | 3.3 × 10−4 | 12 |
| B6 Pgc-1α | 5.7 ± 0.3 | 9.7 ± 0.9 | 1.1 × 10−4 | 12 |
| B × AF1 Pgc-1α | 7.4 ± 0.4 | 9.3 ± 0.6 | 0.02 | 12 |
| BC Ucp1 | 67.4 ± 2 | 77.8 ± 3 | 7.3 × 10−3 | 400 |
| BC Pgc-1α | 8.2 ± 0.2 | 11.7 ± 0.3 | 1.6 × 10−24 | 400 |
A/J, C57BL/6J (B6), (B × A) F1 and backcross mice were exposed to cold at 5°C for 7 days while on chow (4.5 wt% fat, LFD) or high fat diets (36 wt% fat, HFD) from weaning until the end of cold exposure. Pgc-1α mRNA levels increased 43% and Ucp1 levels 15% in backcross mice on a high fat diet.