Table 1.
Structures of IGFBP domains found in the Protein Data Bank (PDB) and Biological Magnetic Resonance Bank (BMRB) databases.
| N-domain | C-domain | IGF-I:N-BP | IGF-I:N-BP:C-BP | |
|---|---|---|---|---|
| IGFBP-1 | 1ZT3 (aa 166–259), 1ZT5 (aa 166–259, Fe2+; Sala et al., 2005)* | |||
| IGFBP-2 | http://rest.bmrb.wisc.edu/bmrb/NMR-STAR2/17743 (Galea et al., 2012)** | 2H7T (aa 183–289; Kuang et al., 2006)# | ||
| IGFBP-4 | 2DSP (IGF-I:N-BP-4 aa 1–92; Sitar et al., 2006)* | 2DSR (IGF-I:N-BP-4 aa 1–92: C-BP-4 aa 151–232; Sitar et al., 2006)* | ||
| IWQJ (IGF-I:N-BP-4, aa 3–82; Siwanowicz et al., 2005)* | 2DSQ (IGF-I:N-BP-4 aa 1–92: C-BP-1 aa 141–234; Sitar et al., 2006)* | |||
| IGFBP-5 | 1BOE (aa 40–92; Kalus et al., 1998)# | 1H59 (IGF-I:N-BP-5, aa 58–111; Zeslawski et al., 2001)* | ||
| IGFBP-6 | 2JM2 (aa 25–69; Chandrashekaran et al., 2007)# | 1RMJ (aa 136–216; Headey et al., 2004a)# |
*Structures determined by X-ray crystallography.
#Structures determined by NMR.
**Model based on NMR data and homology modeling using N-BP-4 coordinates (PDB 2DSP and 2DSR).