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. 2011 Dec 30;2:105. doi: 10.3389/fendo.2011.00105

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Copyright © 2011 Stanley and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

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A model of PG action in hemocytes. A stimulator would be a chemical component of an infecting microorganism, such as LPS or laminarin. As modeled here, a phospholipase A₂ is activated by translocation from the cytosol to intracellular and plasma membranes. The activated phospholipase A₂ releases AA from cellular phospholipid pools. The AA is subsequently converted into PGE₂ or other eicosanoids. PGs are exported from the cell by specific PG transporter proteins. The PGs can interact with receptors located on the exporting cell (autocrine action) or with receptors located on other cells (paracrine action).