Figure 1.

Early clinical features of Werner's syndrome in a 16-year-old female patient from a consanguineous family. (A) Clinical images of proband at (I) 7 years old and (II, III) 16 years old, showing truncal obesity and acanthosis nigricans in the neck and flexures at both ages, and marked loss of distal subcutaneous tissue from the arms by 16 years. (B) Growth chart showing failure of pubertal growth spurt, typical of Werner's syndrome. (C) Pedigree diagram (HOCM, hypertrophic obstructive cardiomyopathy; DM, type II diabetes mellitus).