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. 2011 Oct 10;2:43. doi: 10.3389/fendo.2011.00043

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Copyright © 2011 Hojo, Higo, Kawato, Hatanaka, Ooishi, Murakami, Ishii, Komatsuzaki, Ogiue-Ikeda, Mukai and Kimoto.

This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

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Localization of the enzymes required for synthesis of sex steroids and corticosteroids in the hippocampus. (A) and (B) Immunohistochemical staining of P450(17α) (A) and P450arom (B) in the coronal section of the adult male rat hippocampus. (C–E) In situ hybridization analysis of P450 (11β1) (C), 17β-HSD (type 1) (D) and 5α-reductase (type 1) (E) with antisense probes. All steroidogenic enzymes are mainly expressed in neurons, although a weak expression is observed in some glial cells. Scale bar, 800 μm. Modified from Hojo et al. (2004, 2009), Higo et al. (2011).