Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Oct 28;2:61. doi: 10.3389/fendo.2011.00061

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2011 Tsutsui, Ukena, Sakamoto, Okuyama and Haraguchi.

This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

PMC Copyright notice

Schematic model depicting possible actions of estradiol in the Purkinje cell during development. Estradiol acts on the Purkinje cell through intranuclear receptor (ERβ)-mediated mechanisms that promote dendritic growth, spinogenesis, and synaptogenesis in this neuron by genomic mechanisms. Both Purkinje cells and granule cells express BDNF and TrkB, a receptor for BDNF. Estradiol induces the expression of BDNF, which may act on Purkinje cells and granule cells through TrkB-mediated mechanisms to promote Purkinje dendritic growth, spinogenesis, and synaptogenesis. See the text for details. StAR, steroidogenic acute regulatory protein; P450scc, cytochrome P450 side-chain cleavage enzyme; 3β-HSD, 3β-hydroxysteroid dehydrogenase/Δ⁵-Δ⁴-isomerase; P450_17α,lyase, cytochrome P450 17α-hydroxylase/c17,20-lyase; 17β-HSD, 17β-hydroxysteroid dehydrogenase; P450arom, cytochrome P450 aromatase; ERβ, estrogen receptor-β; ERE, estrogen response element; BDNF, brain-derived neurotrophic factor; TrkB, BDNF receptor.