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Multiple kinases lead to the formation of phospho-degron of Cdc25A under DDR. Under DDR ATR activates Chk1 which then phosphorylates Cdc25A at S76 and turns on NEK11. Consequently, NEK11 phosphorylates Cdc25A at S82, whereas, CK1α phosphorylates both S79 and S82 of Cdc25A. In p53-deficient cells, p38MAPK and MK2 lead to the phosphorylation of S76 under UV damage. Upon the phospho-degron is created, Cdc25A is recognized and ubiquitinated by the SCFβTRCP ubiquitin ligase.
