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. 2011 Nov 22;2:76. doi: 10.3389/fendo.2011.00076

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Copyright © 2011 Ward and Lawrence.

This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

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Domain structure of the human insulin receptor. L1, first leucine-rich repeat domain; CR, cysteine-rich region; L2, second leucine-rich repeat domain; FnIII-1, -2, -3, first, second, and third fibronectin type III domains; ID, insert domain; TM/JM, trans- and juxtamembrane regions; TK, tyrosine kinase domain. The second fibronectin Type III domain and the insert domain span both the α- and the β-chains of the mature protein. The critical C-terminal segment of the α-chain (αCT) is indicated by a red asterisk. Inter-chain and inter-monomer disulfide bonds are indicated by black line segments and membrane and cytoplasmic regions are shown in dashed outline.