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. 2011 Nov 22;2:76. doi: 10.3389/fendo.2011.00076

Figure 5.

Figure 5

(A) Three-dimensional crystal structure of the L1–CR–L2 module of the Type 1 insulin-like growth factor receptor (IGF-1R). (B) View of the molecular surface of the central and third β-sheet of the L1 domain of IGF-1R, highlighting in red those portions of the surface that correspond to equivalent residues within the insulin receptor that have been implicated in hormone binding. (C) Overlay of the L1 domains of insulin receptor (light green) and IGF-1R (light orange), highlighting the difference in side chain disposition of the equivalent residues IR Phe39 and IGF-1R Ser35. Panels are based on PDB entries 1IGR and 2HR7.