Table 1.
Formulations | Composition of the lipid bilayer | Composition of the aqueous phase | Liposome diameter (nm) ± SD | PI ± SD | ζ mV ± SD | Dox encapsulation efficiency (%) |
---|---|---|---|---|---|---|
DSPC liposomes | DSPC | PBS | 161.4 ± 20.1 | 0.09 ± 0.01 | −6.7 ± 1.8 | – |
MonY liposomes | DSPC/MonY-BN | PBS | 145.5 ± 31.5 | 0.20 ± 0.05 | −12.8 ± 1.5 | – |
Dox-MonY liposomes | DSPC/MonY-BN | Ammonium buffer | 165.2 ± 42.0 | 0.24 ± 0.07 | −12.8 ± 3.6 | 58.0 ± 19.0 |
Dox-MonY liposomes | DSPC/MonY-BN | Citrate buffer | 150.8 ± 28.3 | 0.13 ± 0.08 | −12.0 ± 1.0 | 95.0 ± 2.7 |
Abbreviations: Dox, doxorubicin; DSPC, 1,2-distearoyl-sn-glycero-3-phosphocholine; PBS, phosphate-buffered saline; PI, polydispersity index; SD, standard deviation.